Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism

Abstract Background Trichophyton rubrum is the main etiological agent of skin and nail infections worldwide. Because of its keratinolytic activity and anthropophilic nature, infection models based on the addition of protein substrates have been employed to assess transcriptional profiles and to eluc...

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Detalhes bibliográficos
Main Authors: Tamires Aparecida Bitencourt, Claudia Macedo, Matheus Eloy Franco, Marina Campos Rocha, Igor Sawasaki Moreli, Bruna Aline Micheloto Cantelli, Pablo Rodrigo Sanches, Rene Oliveira Beleboni, Iran Malavazi, Geraldo Aleixo Passos, Mozart Marins, Ana Lúcia Fachin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-05-01
Colecção:BMC Genomics
Assuntos:
Chalcone
CWI
Elastin
Keratin
Dermatophyte
Transcriptional profile
Acesso em linha:http://link.springer.com/article/10.1186/s12864-019-5792-0
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