The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease

Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe disease, is associated with secreted EVs. We e...

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Bibliografiska uppgifter
Huvudupphovsmän: Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Koralege C. Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publishing 2022-03-01
Serie:ASN Neuro
Länkar:https://doi.org/10.1177/17590914221087817
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