Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (−) and ER (+) Breast Cancer

Bcl-2 is overexpressed in about a half of human cancers and 50–70% of breast cancer patients, thereby conferring resistance to conventional therapies and making it an excellent therapeutic target. Small interfering RNA (siRNA) offers novel and powerful tools for specific gene silencing and molecular...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Ibrahim Tekedereli, S Neslihan Alpay, Ugur Akar, Erkan Yuca, Cristian Ayugo-Rodriguez, He-Dong Han, Anil K Sood, Gabriel Lopez-Berestein, Bulent Ozpolat
格式: Artigo
語言:Inglês
出版: Elsevier 2013-01-01
叢編:Molecular Therapy: Nucleic Acids
主題:
apoptosis
autophagy
Bcl-2
breast cancer
chemotherapy
estrogen receptor
gene silencing
liposome
nanoparticles
nanotherapeutics
programmed cell deathsiRNA
在線閱讀:http://www.sciencedirect.com/science/article/pii/S2162253116301780
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍