Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration

The two major proteins involved in Alzheimer’s disease (AD) are the amyloid precursor protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other. Four possible peptides APP1 (390–412), APP2 (713–730), Tau1 (19–34) and Tau2 (331–348), were predicted to be involved in t...

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Hlavní autoři: Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arnon
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-05-01
Edice:International Journal of Molecular Sciences
Témata:
APP and Tau protein
synthetic peptides
Alzheimer’s disease
cognitive function
amyloid plaques
On-line přístup:https://www.mdpi.com/1422-0067/21/9/3270
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