Peptide Interference with APP and Tau Association: Relevance to Alzheimer’s Disease Amelioration

The two major proteins involved in Alzheimer’s disease (AD) are the amyloid precursor protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other. Four possible peptides APP1 (390–412), APP2 (713–730), Tau1 (19–34) and Tau2 (331–348), were predicted to be involved in t...

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Detalhes bibliográficos
Main Authors: Ruth Maron, Gad Armony, Michael Tsoory, Meir Wilchek, Dan Frenkel, Ruth Arnon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-05-01
Colecção:International Journal of Molecular Sciences
Assuntos:
APP and Tau protein
synthetic peptides
Alzheimer’s disease
cognitive function
amyloid plaques
Acesso em linha:https://www.mdpi.com/1422-0067/21/9/3270
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