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Promoter Hypomethylation and miR-145-5p Downregulation- Mediated HDAC11 Overexpression Promotes Sorafenib Resistance and Metastasis of Hepatocellular Carcinoma Cells

Sorafenib resistance and tumor metastasis account for poor outcome of hepatocellular carcinoma (HCC). Histone deacetylase 11 (HDAC11) has been reported to exert oncogenic effects in several types of human cancer, but its specific functions and detailed mechanisms in HCC are not fully elucidated. Her...

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Bibliografski detalji
Glavni autori: Wenlong Wang, Bisha Ding, Weiyang Lou, Shengyou Lin
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020-08-01
Serija:Frontiers in Cell and Developmental Biology
Teme:
Online pristup:https://www.frontiersin.org/article/10.3389/fcell.2020.00724/full
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