ProBDNF promotes sepsis-associated encephalopathy in mice by dampening the immune activity of meningeal CD4+ T cells

Abstract Background Sepsis-associated encephalopathy (SAE) increases the mortality of septic patients, but its mechanism remains unclear. The present study aimed to investigate the roles of T lymphocytes, proBDNF, and their interaction in the pathogenesis of SAE. Methods Fear conditioning tests were...

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Detalhes bibliográficos
Main Authors: Ru-Yi Luo, Cong Luo, Feng Zhong, Wei-Yun Shen, Hui Li, Zhao-Lan Hu, Ru-Ping Dai
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-05-01
Colecção:Journal of Neuroinflammation
Assuntos:
Sepsis
Encephalopathy
Meningeal immunity
CD4+ T cells
Brain-derived neurotrophic factor precursor
Monoclonal antibody
Acesso em linha:http://link.springer.com/article/10.1186/s12974-020-01850-0
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