The Inhibitory Action of Kohamaic Acid A Derivatives on Mammalian DNA Polymerase β

We previously isolated a novel natural product, designated kohamaic acid A (KA-A, compound 1), as an inhibitor of the first cleavage of fertilized sea urchin eggs, and found that this compound could selectively inhibit the activities of mammalian DNA polymerases (pols). In this paper, we investigate...

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Main Authors: Yoshiyuki Mizushina, Daisuke Manita, Toshifumi Takeuchi, Yuko Kumamoto-Yonezawa, Yuki Matsui, Fumio Sugawara, Masaharu Takemura, Hirosato Takikawa, Hiromi Yoshida, Mitsuru Sasaki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2008-12-01
Colecção:Molecules
Assuntos:
Kohamaic acid A (KA-A)
DNA polymerase (DNA-directed DNA polymerase [E.C. 2.7.7.7]
pol)
Enzyme inhibitor
Cytotoxicity
Computer simulation
Acesso em linha:http://www.mdpi.com/1420-3049/14/1/102/
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