Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants.

The use of computational modeling algorithms to guide the design of novel enzyme catalysts is a rapidly growing field. Force-field based methods have now been used to engineer both enzyme specificity and activity. However, the proportion of designed mutants with the intended function is often less t...

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Autores principales: Dylan Alexander Carlin, Ryan W Caster, Xiaokang Wang, Stephanie A Betzenderfer, Claire X Chen, Veasna M Duong, Carolina V Ryklansky, Alp Alpekin, Nathan Beaumont, Harshul Kapoor, Nicole Kim, Hosna Mohabbot, Boyu Pang, Rachel Teel, Lillian Whithaus, Ilias Tagkopoulos, Justin B Siegel
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2016-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC4729467?pdf=render
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