Kinetic Characterization of 100 Glycoside Hydrolase Mutants Enables the Discovery of Structural Features Correlated with Kinetic Constants.

The use of computational modeling algorithms to guide the design of novel enzyme catalysts is a rapidly growing field. Force-field based methods have now been used to engineer both enzyme specificity and activity. However, the proportion of designed mutants with the intended function is often less t...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dylan Alexander Carlin, Ryan W Caster, Xiaokang Wang, Stephanie A Betzenderfer, Claire X Chen, Veasna M Duong, Carolina V Ryklansky, Alp Alpekin, Nathan Beaumont, Harshul Kapoor, Nicole Kim, Hosna Mohabbot, Boyu Pang, Rachel Teel, Lillian Whithaus, Ilias Tagkopoulos, Justin B Siegel
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science (PLoS) 2016-01-01
سلاسل:PLoS ONE
الوصول للمادة أونلاين:http://europepmc.org/articles/PMC4729467?pdf=render
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