Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia

Abstract Background Microglial cell-associated neuroinflammation is considered as a potential contributor to the pathophysiology of sporadic amyotrophic lateral sclerosis. However, the specific role of microglia in the disease pathogenesis remains to be elucidated. Methods We studied the activation...

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Main Authors: Pooja-Shree Mishra, K. Vijayalakshmi, A. Nalini, T. N. Sathyaprabha, B. W. Kramer, Phalguni Anand Alladi, T. R. Raju
Format: Artigo
Jezik:Inglês
Izdano: BMC 2017-12-01
Serija:Journal of Neuroinflammation
Teme:
Sporadic ALS
Microglia
ALS-CSF
Neuroinflammation
Non-cell autonomous pathology
Chitotriosidase
Online dostop:http://link.springer.com/article/10.1186/s12974-017-1028-x
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