A Cell-Level Systems PK-PD Model to Characterize In Vivo Efficacy of ADCs

Here, we have presented the development of a systems pharmacokinetics-pharmacodynamics (PK-PD) model for antibody-drug conjugates (ADCs), which uses intracellular target occupancy to drive in-vivo efficacy. The model is built based on PK and efficacy data generated using Trastuzumab-Valine-Citrullin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Aman P. Singh, Leiming Guo, Ashwni Verma, Gloria Gao-Li Wong, Dhaval K. Shah
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-02-01
Colecção:Pharmaceutics
Assuntos:
Antibody-drug conjugates
cellular pharmacokinetics
tumor pharmacokinetics
PK-PD model
in vivo efficacy
Trastuzumab-vc-MMAE
tubulin occupancy
Acesso em linha:https://www.mdpi.com/1999-4923/11/2/98
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados