Activity of D-amino acid oxidase is widespread in the human central nervous system

It has been proposed that D-amino acid oxidase (DAO) plays an essential role in degrading D-serine, an endogenous coagonist of N-methyl-D-aspartate (NMDA) glutamate receptors. DAO shows genetic association with amyotrophic lateral sclerosis (ALS) and schizophrenia, in whose pathophysiology aberrant...

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Detalhes bibliográficos
Main Authors: Jumpei eSasabe, Masataka eSuzuki, Nobuaki eImanishi, Sadakazu eAiso
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014-06-01
Colecção:Frontiers in Synaptic Neuroscience
Assuntos:
Amyotrophic Lateral Sclerosis
Schizophrenia
human brain
white matter
d-serine
motor systems
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnsyn.2014.00014/full
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