The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Thoracoabdominal aortic aneurysm (TAAA) is a highly lethal disorder requiring open or endovascular TAAA repair, both of which are rare, but extensive and complex surgical procedures associated with a significant systemic inflammatory response and high post-operative morbidity and mortality. Heparana...

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Detalhes bibliográficos
Main Authors: Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-06-01
Colecção:Frontiers in Immunology
Assuntos:
glycosaminoglycan
vascular surgery
syndecan-1
heparan sulfate
heparanase
perioperative care
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00681/full
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