Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy

ABSTRACT Aim: to analyze the effect of metformin on ammonia production derived from glutamine metabolism in vitro and in vivo. Methods: twenty male Wistar rats were studied for 28 days after a porto-caval anastomosis (n = 16) or a sham operation (n = 4). Porto-caval shunted animals were randomized...

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Auteurs principaux: Antonio Gil-Gómez, Ana-Isabel Gómez-Sotelo, Isidora Ranchal, Ángela Rojas, Marta García-Valdecasas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Javier Ampuero, Manuel Romero-Gómez
Format: Artigo
Langue:Inglês
Publié: Aran Ediciones
Collection:Revista Espanola de Enfermedades Digestivas
Sujets:
Hepatic encephalopathy
Metformin
Ammonia
Glutaminase
Glutamine
Cirrhosis
ASCT2
mTOR
Porto-caval anastomosis
Accès en ligne:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082018000700004&lng=en&tlng=en
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