Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy

Hepatitis C virus (HCV) infection has been related to increased risk of development of hepatocellular carcinoma (HCC) while metformin (M) and statins treatment seemed to protect against HCC development. In this work, we aim to identify the mechanisms by which metformin and simvastatin (S) could prot...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: del Campo, José A., García-Valdecasas, Marta, Gil-Gómez, Antonio, Rojas, Ángela, Gallego, Paloma, Ampuero, Javier, Gallego-Durán, Rocío, Pastor, Helena, Grande, Lourdes, Padillo, Francisco J., Muntané, Jordi, Romero-Gómez, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791999/
https://ncbi.nlm.nih.gov/pubmed/29385181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191805
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