Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings

Mouse cortical GABAergic synaptosomes possess presynaptic inhibitory GABAB autoreceptors. Accordingly, (±)baclofen (3 μM) inhibits in a CGP53423-sensitive manner the 12 mM KCl-evoked release of preloaded [3H]GABA. Differently, the existence of presynaptic release-regulating metabotropic glutamate ty...

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Bibliographic Details
Main Authors: Matteo Vergassola, Guendalina Olivero, Francesca Cisani, Cesare Usai, Simone Bossi, Aldamaria Puliti, Anna Pittaluga
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mGlu1 receptor
GABAB receptor
receptor–receptor interaction
Grm1crv4/crv4 mice
release
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00324/full
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