Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Abstract Background Using a pathway-focused approach, we aimed to provide a subgroup-specific basis for finding novel therapeutic strategies and further refinement of the risk stratification in pediatric medulloblastoma. Method Based on genome-wide Cox regression and Gene Set Enrichment Analysis, we...

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Main Authors: Ae Kyung Park, Ji Yeoun Lee, Heesun Cheong, Vijay Ramaswamy, Sung-Hye Park, Marcel Kool, Ji Hoon Phi, Seung Ah Choi, Florence Cavalli, Michael D. Taylor, Seung-Ki Kim
Format: Artigo
Jezik:Inglês
Izdano: BMC 2019-06-01
Serija:BMC Cancer
Teme:
Medulloblastoma
Subgroup
Prognosis
Signaling pathway
Metabolic pathway
Targeted therapy
Online dostop:http://link.springer.com/article/10.1186/s12885-019-5742-x
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