Αποτελέσματα αναζήτησης - Marcel Kool

Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma από Foteini Tsiami, Chiara Lago, Noemi Pozza, Federica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E. Root, Luca Tiberi, Marcel Kool, Jens Schittenhelm, Pratiti Bandopadhayay, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk

Λήψη πλήρους κειμένου

Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling από Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David T.W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

Λήψη πλήρους κειμένου

Correction: Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling από Konstantin Okonechnikov, David R. Ghasemi, Daniel Schrimpf, Svenja Tonn, Martin Mynarek, Jan Koster, Till Milde, Tuyu Zheng, Philipp Sievers, Felix Sahm, David T.W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Kristian W. Pajtler, Andrey Korshunov

Λήψη πλήρους κειμένου

Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments από Chiara Lago, Aniello Federico, Gloria Leva, Norman L Mack, Benjamin Schwalm, Claudio Ballabio, Matteo Gianesello, Luana Abballe, Isabella Giovannoni, Sofia Reddel, Sabrina Rossi, Nicolas Leone, Andrea Carai, Angela Mastronuzzi, Alessandra Bisio, Alessia Soldano, Concetta Quintarelli, Franco Locatelli, Marcel Kool, Evelina Miele, Luca Tiberi

Λήψη πλήρους κειμένου

Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth από Evelina Miele, Agnese Po, Angela Mastronuzzi, Andrea Carai, Zein Mersini Besharat, Natalia Pediconi, Luana Abballe, Giuseppina Catanzaro, Claudia Sabato, Enrico De Smaele, Gianluca Canettieri, Lucia Di Marcotullio, Alessandra Vacca, Antonello Mai, Massimo Levrero, Stefan M. Pfister, Marcel Kool, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti

Λήψη πλήρους κειμένου

Mitochondrial DNA mutations in Medulloblastoma από Viktoria L. E. Funke, Sarah Sandmann, Viktoria Melcher, Jochen Seggewiss, Judit Horvath, Natalie Jäger, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Till Milde, Stefan Rutkowski, Martin Mynarek, Julian Varghese, Ronald Sträter, Stephan Rust, Anja Seelhöfer, Janine Reunert, Barbara Fiedler, Ulrich Schüller, Thorsten Marquardt, Kornelius Kerl

Λήψη πλήρους κειμένου

The potential of PARP as a therapeutic target across pediatric solid malignancies από Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar, Sander R. van Hooff

Λήψη πλήρους κειμένου

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions από Dr. Lisa Gabler-Pamer, Dr. Alexander Beck, Ms McKenzie Shaw, Olivia A. Hack, Dr. Sibylle Madlener, Dr. Daniela Lötsch, Dr Dr. Irene Slavc, Dr. Christian Dorfer, Dr. Christine Haberler, Dr. Lissa Baird, Dr. Susan N. Chi, Dr. Sanda Alexandrescu, Dr. Johannes Gojo, Dr. Marcel Kool, Dr. Volker Hovestadt, Dr. Mariella G. Filbin

Λήψη πλήρους κειμένου

Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach από Julia K. Sundheimer, Julia Benzel, Aniello Federico, Stefanie Volz, Maximilian Knoll, Britta Statz, Tuyu Zheng, Szymon W. Kmiecik, Jürgen Burhenne, Gzona Bajraktari-Sylejmani, Sophia Scheuermann, Anke King, Torsten Müller, Jens-Martin Hübner, Mathias Kalxdorf, Heike Peterziel, Ina Oehme, Jeroen Krijgsveld, Christian M. Seitz, Marcel Kool, Stefan M. Pfister, Kristian W. Pajtler, Kendra K. Maaß

Λήψη πλήρους κειμένου

Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours από Arash Nabbi, Pengbo Beck, Alberto Delaidelli, Derek A. Oldridge, Sumedha Sudhaman, Kelsey Zhu, S. Y. Cindy Yang, David T. Mulder, Jeffrey P. Bruce, Joseph N. Paulson, Pichai Raman, Yuankun Zhu, Adam C. Resnick, Poul H. Sorensen, Martin Sill, Sebastian Brabetz, Sander Lambo, David Malkin, Pascal D. Johann, Marcel Kool, David T. W. Jones, Stefan M. Pfister, Natalie Jäger, Trevor J. Pugh

Λήψη πλήρους κειμένου

Author Correction: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors από Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst

Λήψη πλήρους κειμένου

Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion από Yulun Huang, Lin Qi, Mari Kogiso, Yuchen Du, Frank K. Braun, Huiyuan Zhang, L. Frank Huang, Sophie Xiao, Wan‐Yee Teo, Holly Lindsay, Sibo Zhao, Patricia Baxter, Jack M. F. Su, Adekunle Adesina, Jianhua Yang, Sebastian Brabetz, Marcel Kool, Stefan M. Pfister, Murali Chintagumpala, Laszlo Perlaky, Zhong Wang, Youxin Zhou, Tsz‐Kwong Man, Xiao‐Nan Li

Λήψη πλήρους κειμένου

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma από Anna S. Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty, Jürgen Burhenne, Shunya Ohmura, Tim Holland-Letz, Lena M. Kutscher, Aurélie Ernst, Pei-Chi Wei, Thomas G.P. Grünewald, Ina Oehme, Marcel Kool, David T.W. Jones, Kristian W. Pajtler, Christian P. Kratz, Stefan M. Pfister, Olaf Witt, Till Milde

Λήψη πλήρους κειμένου

Therapy and biomarker dependent progression-free survival in infant sonic hedgehog medulloblastoma: a multi-national retrospective cohort studyResearch in context από Stacey Richardson, Debbie Hicks, Melissa Gough, Ellie R. Butler, Dean Thompson, Jemma Castle, Stephen Crosier, Miguel Garcia-Ariza, Idoia Martín-Guerrero, Sabine L.A. Plasschaert, Franck Bourdeaut, Christelle Dufour, Julien Masliah-Planchon, Francesca Romana Buttarelli, Veronica Biassoni, Maura Massimino, Koichi Ichimura, Yonehiro Kanemura, Vijay Ramaswamy, Amar Gajjar, Marcel Kool, Andrey Korshunov, Stefan M. Pfister, Martin Mynarek, Stefan Rutkowski, Edward C. Schwalbe, Simon Bailey, Steven C. Clifford

Λήψη πλήρους κειμένου

Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury από Laura M. Williamson, Craig M. Rive, Daniela Di Francesco, Emma Titmuss, Hye-Jung E. Chun, Scott D. Brown, Katy Milne, Erin Pleasance, Anna F. Lee, Stephen Yip, Daniel G. Rosenbaum, Martin Hasselblatt, Pascal D. Johann, Marcel Kool, Melissa Harvey, David Dix, Daniel J. Renouf, Robert A. Holt, Brad H. Nelson, Martin Hirst, Steven J. M. Jones, Janessa Laskin, Shahrad R. Rassekh, Rebecca J. Deyell, Marco A. Marra

Λήψη πλήρους κειμένου

Co-targeting CDK4/6 and MEK reverses mesenchymal transition in therapy-refractory BRAF-altered pediatric high-grade glioma από Lisa Mayr, Leah Mager, Lisa Gabler-Pamer, Dominik Kirchhofer, Julia Freund, Kallen Schwark, Benison Lau, Sarah Machreich, Daniel Senfter, Mia Neumüller, Alexandra Lang, Sibylle Madlener, Anna Laemmerer, Katharina Bruckner, Carola N. Jaunecker, Bernhard Robl, Romina Walter, Julia Schueler, Andreas Peyrl, Amedeo A. Azizi, Christian Dorfer, Karl Roessler, Sabine Spiegl-Kreinecker, Christine Haberler, Aniello Federico, Apurva Gopisetty, Gudrun Schleiermacher, Stefan M. Pfister, Birgit Geoerger, Louis Chesler, Gilles Vassal, Marcel Kool, Leonhard Müllauer, Carl Koschmann, Walter Berger, Johannes Gojo, Daniela Lötsch

Λήψη πλήρους κειμένου

Ex vivo drug sensitivity profiling to complement molecular profiling in pediatric precision oncology από Marlinde C. Schoonbeek, Pierre Gestraud, Lindy Vernooij, Arjan Boltjes, Vicky Amo-Addae, Marloes van Luik, Elaine Del Nery, Angela Bellini, Ellora Chua, Sarah Swaak, Eleonora J. Looze, Vilja M. Pietiäinen, Laura L. Turunen, Jani S. Saarela, Julia Schueler, Emilie Indersie, Dennis Gürgen, Katia Scotlandi, Angelika Eggert, Rachida Bouarich-Bourimi, Franck Bourdeaut, Sakina Zaidi, Didier Surdez, Ángel M. Carcaboso, Birgit Geoerger, Aniello Federico, Marcel Kool, Yasmine Iddir, Alexandra Saint-Charles, Elnaz Saberi-Ansari, Florence Cavalli, Apurva Gopisetty, Eva Maria Rief, Hubert N. Caron, Lou Stancato, Gilles Vassal, Stefan Pfister, Jan Koster, Selma Eising, Sander R. van Hooff, Marlinde L. van den Boogaard, Gudrun Schleiermacher, Jan J. Molenaar

Λήψη πλήρους κειμένου

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma από Konstantin Okonechnikov, Aylin Camgöz, Owen Chapman, Sameena Wani, Donglim Esther Park, Jens-Martin Hübner, Abhijit Chakraborty, Meghana Pagadala, Rosalind Bump, Sahaana Chandran, Katerina Kraft, Rocio Acuna-Hidalgo, Derek Reid, Kristin Sikkink, Monika Mauermann, Edwin F. Juarez, Anne Jenseit, James T. Robinson, Kristian W. Pajtler, Till Milde, Natalie Jäger, Petra Fiesel, Ling Morgan, Sunita Sridhar, Nicole G. Coufal, Michael Levy, Denise Malicki, Charlotte Hobbs, Stephen Kingsmore, Shareef Nahas, Matija Snuderl, John Crawford, Robert J. Wechsler-Reya, Tom Belle Davidson, Jennifer Cotter, George Michaiel, Gudrun Fleischhack, Stefan Mundlos, Anthony Schmitt, Hannah Carter, Kulandaimanuvel Antony Michealraj, Sachin A. Kumar, Michael D. Taylor, Jeremy Rich, Frank Buchholz, Jill P. Mesirov, Stefan M. Pfister, Ferhat Ay, Jesse R. Dixon, Marcel Kool, Lukas Chavez

Λήψη πλήρους κειμένου