DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning

Abstract Recent technological advances have enabled DNA methylation to be assayed at single-cell resolution. However, current protocols are limited by incomplete CpG coverage and hence methods to predict missing methylation states are critical to enable genome-wide analyses. We report DeepCpG, a com...

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Autori principali: Christof Angermueller, Heather J. Lee, Wolf Reik, Oliver Stegle
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2017-04-01
Serie:Genome Biology
Soggetti:
Deep learning
Artificial neural network
Machine learning
Single-cell genomics
DNA methylation
Epigenetics
Accesso online:http://link.springer.com/article/10.1186/s13059-017-1189-z
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