Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy

Abstract Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily conserved process which maintains cellular homeostasis and eliminates damaged cellular components. Moreover, the STAT...

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Hauptverfasser: Shichong Lin, Lehe Yang, Yulei Yao, Lingyuan Xu, Youqun Xiang, Haiyang Zhao, Liangxing Wang, Zhigui Zuo, Xiaoying Huang, Chengguang Zhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2019-07-01
Schriftenreihe:Journal of Experimental & Clinical Cancer Research
Schlagworte:
Flubendazole
Colorectal cancer
STAT3
Autophagy
Apoptosis
Online Zugang:http://link.springer.com/article/10.1186/s13046-019-1303-z
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