Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome‐enriched vesicles

Abstract Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol‐derived metabolite. It is a new cl...

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Autori principali: Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin‐Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente‐Poirot, Philippe de Medina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2022-04-01
Serie:Journal of Extracellular Vesicles
Soggetti:
bis(monoacylglycero)phosphate
cancer
cholesterol
dendrogenin A
differentiation
exosomes
Accesso online:https://doi.org/10.1002/jev2.12211
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