Schizophrenia risk and reproductive success: a Mendelian randomization study

Schizophrenia is a debilitating and heritable mental disorder associated with lower reproductive success. However, the prevalence of schizophrenia is stable over populations and time, resulting in an evolutionary puzzle: how is schizophrenia maintained in the population, given its apparent fitness c...

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Autori principali: Rebecca B. Lawn, Hannah M. Sallis, Amy E. Taylor, Robyn E. Wootton, George Davey Smith, Neil M. Davies, Gibran Hemani, Abigail Fraser, Ian S. Penton-Voak, Marcus R. Munafò
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2019-03-01
Serie:Royal Society Open Science
Soggetti:
schizophrenia
mendelian randomization
stabilizing selection
cliff-edge fitness
reproductive success
Accesso online:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.181049
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