The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury

Abstract Traumatic injury to the spinal cord initiates a series of pathological cellular processes that exacerbate tissue damage at and beyond the original site of injury. This secondary damage includes oxidative stress and inflammatory cascades that can lead to further neuronal loss and motor defic...

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Bibliographic Details
Main Authors: Madhuvika Murugan, Jiaying Zheng, Gongxiong Wu, Rochelle Mogilevsky, Xin Zheng, Peiwen Hu, Junfang Wu, Long-Jun Wu
Format: Artigo
Language:Inglês
Published: BMC 2020-10-01
Series:Molecular Brain
Subjects:
Microglia
Spinal cord injury
Hv1
Voltage-gated proton channel
ROS
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s13041-020-00682-6
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