Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

We designed, synthesized, and evaluated novel 2,6,9-trisubstituted purine derivatives for their prospective role as antitumor compounds. Using simple and efficient methodologies, 31 compounds were obtained. We tested these compounds in vitro to draw conclusions about their cell toxicity on seven can...

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Detalhes bibliográficos
Main Authors: Cristian O. Salas, Ana Maria Zarate, Vladimir Kryštof, Jaime Mella, Mario Faundez, Jose Brea, María Isabel Loza, Ivan Brito, Denisa Hendrychová, Radek Jorda, Alan R. Cabrera, Ricardo A. Tapia, Christian Espinosa-Bustos
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2019-12-01
Colecção:International Journal of Molecular Sciences
Assuntos:
cancer
purine derivatives
cytotoxicity
3d-qsar
apoptosis
cell cycle
Acesso em linha:https://www.mdpi.com/1422-0067/21/1/161
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