Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

Enzymes in the thiol redox systems of microbial pathogens are promising targets for drug development. In this study we characterized the thioredoxin reductase (TrxR) selenoproteins from Brugia malayi and Onchocerca volvulus, filarial nematode parasites and causative agents of lymphatic filariasis an...

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Main Authors: Francesca Fata, Radosveta Gencheva, Qing Cheng, Rachel Lullo, Matteo Ardini, Ilaria Silvestri, Federica Gabriele, Rodolfo Ippoliti, Christina A. Bulman, Judy A. Sakanari, David L. Williams, Elias S.J. Arnér, Francesco Angelucci
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2022-05-01
Sraith:Redox Biology
Ábhair:
Thioredoxin reductase
Glutaredoxin
Selenocysteine
X-ray crystallography
Auranofin
Thioredoxin reductase inhibitor
Rochtain Ar Líne:http://www.sciencedirect.com/science/article/pii/S2213231722000507
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