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Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer.

Genome-wide association studies typically target inherited autosomal variants, but less studied genetic mechanisms can play a role in complex disease. Sex-linked variants aside, three genetic phenomena can induce differential risk in maternal versus paternal lineages of affected individuals: 1. mate...

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Detalhes bibliográficos
Main Authors: Clarice R Weinberg, Min Shi, Lisa A DeRoo, Jack A Taylor, Dale P Sandler, David M Umbach
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-03-01
Colecção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC3961172?pdf=render
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