A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have significant adverse effects. One approach is targeting...

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Main Authors: Yulia A. Sidorova, Maxim M. Bespalov, Agnes W. Wong, Oleg Kambur, Viljami Jokinen, Tuomas O. Lilius, Ilida Suleymanova, Gunnar Karelson, Pekka V. Rauhala, Mati Karelson, Peregrine B. Osborne, Janet R. Keast, Eija A. Kalso, Mart Saarma
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-06-01
Colecção:Frontiers in Pharmacology
Assuntos:
neuropathic pain
glial cell line-derived neurotrophic factor (GDNF)
GDNF family ligands (GFLs)
artemin (ARTN)
small molecule RET agonist
GFL mimetic
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphar.2017.00365/full
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