AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway

Glioblastoma multiforme (GBM) is the most common intracranial malignancy in adults with the highest degree of malignancy and mortality. Due to its nature of diffuse invasiveness and high migration, GBM lacks an effective treatment strategy and is associated with poor prognosis. SC66 is a novel AKT i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lun Gao, Junhui Liu, Pengfei Xu, Gang Deng, Baohui Liu, Fanen Yuan, Yinqiu Tan, Qian Sun, Yang Xu, Huikai Zhang, Yangzhi Qi, Shoumeng Han, Kun Yang, Rongxin Geng, Hongxiang Jiang, Qianxue Chen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020-07-01
Cyfres:Frontiers in Pharmacology
Pynciau:
SC66
glioblastoma multiforme
epithelial-to-mesenchymal transition
proliferation
apoptosis
AKT/β-catenin pathway
Mynediad Ar-lein:https://www.frontiersin.org/article/10.3389/fphar.2020.01102/full
Tagiau: Ychwanegu Tag
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