High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response

ABSTRACT Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the ability to predict and evaluate viral protein bioactivit...

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Main Authors: Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Roger L. Chang, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2022-04-01
Colecção:mSystems
Assuntos:
expression systems
virus-host interactions
Acesso em linha:https://journals.asm.org/doi/10.1128/msystems.01466-21
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