P81 Antibody to Cardiotonic Steroid Reduces Blood Pressure and Vascular Fibrosis in Preeclampsia

Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). We demonstrated that MBG induces fibrosis via mechanism involving inhibition of Fli1, a nuclear transcription factor and a negative regulator...

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Hauptverfasser: NI Agalakova, VA Reznik, OV Nadei, IA Ershov, OS Rassokha, ML Vasyutina, MM Galagudza, AY Bagrov
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2020-02-01
Schriftenreihe:Artery Research
Online Zugang:https://www.atlantis-press.com/article/125934561/view
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