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Assessment of algorithms for inferring positional weight matrix motifs of transcription factor binding sites using protein binding microarray data.

The new technology of protein binding microarrays (PBMs) allows simultaneous measurement of the binding intensities of a transcription factor to tens of thousands of synthetic double-stranded DNA probes, covering all possible 10-mers. A key computational challenge is inferring the binding motif from...

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Autors principals: Yaron Orenstein, Chaim Linhart, Ron Shamir
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2012-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC3460961?pdf=render
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