Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020-09-01
Sraith:Frontiers in Immunology
Ábhair:
LKB1
2′3′-cGAMP
STING
KRAS
T cell
endothelial cells
Rochtain Ar Líne:https://www.frontiersin.org/article/10.3389/fimmu.2020.02090/full
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla