Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Campisi, Marco, Sundararaman, Shriram K., Shelton, Sarah E., Knelson, Erik H., Mahadevan, Navin R., Yoshida, Ryohei, Tani, Tetsuo, Ivanova, Elena, Cañadas, Israel, Osaki, Tatsuya, Lee, Sharon Wei Ling, Thai, Tran, Han, Saemi, Piel, Brandon P., Gilhooley, Sean, Paweletz, Cloud P., Chiono, Valeria, Kamm, Roger D., Kitajima, Shunsuke, Barbie, David A.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507350/
https://ncbi.nlm.nih.gov/pubmed/33013881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02090
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