Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

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書誌詳細
主要な著者: Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2020-09-01
シリーズ:Frontiers in Immunology
主題:
LKB1
2′3′-cGAMP
STING
KRAS
T cell
endothelial cells
オンライン･アクセス:https://www.frontiersin.org/article/10.3389/fimmu.2020.02090/full
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