Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020-09-01
Saila:Frontiers in Immunology
Gaiak:
LKB1
2′3′-cGAMP
STING
KRAS
T cell
endothelial cells
Sarrera elektronikoa:https://www.frontiersin.org/article/10.3389/fimmu.2020.02090/full
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