Tumor-Derived cGAMP Regulates Activation of the Vasculature

Intratumoral recruitment of immune cells following innate immune activation is critical for anti-tumor immunity and involves cytosolic dsDNA sensing by the cGAS/STING pathway. We have previously shown that KRAS-LKB1 (KL) mutant lung cancer, which is resistant to PD-1 blockade, exhibits silencing of...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Marco Campisi, Shriram K. Sundararaman, Sarah E. Shelton, Erik H. Knelson, Navin R. Mahadevan, Ryohei Yoshida, Tetsuo Tani, Elena Ivanova, Israel Cañadas, Tatsuya Osaki, Sharon Wei Ling Lee, Tran Thai, Saemi Han, Brandon P. Piel, Sean Gilhooley, Cloud P. Paweletz, Valeria Chiono, Roger D. Kamm, Shunsuke Kitajima, David A. Barbie
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2020-09-01
Σειρά:Frontiers in Immunology
Θέματα:
LKB1
2′3′-cGAMP
STING
KRAS
T cell
endothelial cells
Διαθέσιμο Online:https://www.frontiersin.org/article/10.3389/fimmu.2020.02090/full
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