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A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein.

Novel strategies are needed for the elicitation of broadly neutralizing antibodies to the HIV envelope glycoprotein, gp120. Experimental evidence suggests that combinations of antibodies that are broadly neutralizing in vitro may protect against challenge with HIV in nonhuman primates, and a small n...

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Главные авторы: Hanna C Kelker, Vincenza R Itri, Fred T Valentine
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2010-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC2797330?pdf=render
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