A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein.

Novel strategies are needed for the elicitation of broadly neutralizing antibodies to the HIV envelope glycoprotein, gp120. Experimental evidence suggests that combinations of antibodies that are broadly neutralizing in vitro may protect against challenge with HIV in nonhuman primates, and a small n...

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Main Authors: Hanna C Kelker, Vincenza R Itri, Fred T Valentine
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2010-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC2797330?pdf=render
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