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Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Background: Sepsis and acute respiratory distress syndrome are two heterogeneous acute illnesses with high risk of death and for which there are many ‘statistically negative’ randomised controlled trials. We hypothesised that negative randomised controlled trials occur because of between-participant...

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Những tác giả chính:	Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, Daniel F McAuley
Định dạng:	Artigo
Ngôn ngữ:	Inglês
Được phát hành:	NIHR Journals Library 2021-07-01
Loạt:	Efficacy and Mechanism Evaluation
Những chủ đề:	sepsis ards randomised controlled trials heterogeneity in treatment effect phenotypes latent class
Truy cập trực tuyến:	https://doi.org/10.3310/eme08100
Các nhãn:	Thêm thẻ Không có thẻ, Là người đầu tiên thẻ bản ghi này!

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

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