Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Background: Sepsis and acute respiratory distress syndrome are two heterogeneous acute illnesses with high risk of death and for which there are many ‘statistically negative’ randomised controlled trials. We hypothesised that negative randomised controlled trials occur because of between-participant...

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Main Authors: Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, Daniel F McAuley
Formáid: Artigo
Teanga:Inglês
Foilsithe: NIHR Journals Library 2021-07-01
Sraith:Efficacy and Mechanism Evaluation
Ábhair:
sepsis
ards
randomised controlled trials
heterogeneity in treatment effect
phenotypes
latent class
Rochtain Ar Líne:https://doi.org/10.3310/eme08100
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