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Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

The receptor tyrosine kinase inhibitor lapatinib, indicated to treat patients with HER2-positive breast cancer in combination with capecitabine, can cause severe hepatotoxicity. Lapatinib is further associated with mitochondrial toxicity and accumulation of reactive oxygen species. The effect of lap...

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Main Authors: Noëmi Johanna Roos, Diell Aliu, Jamal Bouitbir, Stephan Krähenbühl
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020-06-01
Sraith:Frontiers in Pharmacology
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Rochtain Ar Líne:https://www.frontiersin.org/article/10.3389/fphar.2020.00944/full
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