Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development

ABSTRACT Cryptococcus neoformans is a major fungal pathogen that often causes life-threatening meningitis in immunocompromised populations. This yeast pathogen is highly resistant to the echinocandin drug caspofungin. Previous studies showed that Cryptococcus lipid translocase (flippase) is required...

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Autores principales: Robert J. Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R. Wiedman
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2022-04-01
Colección:Microbiology Spectrum
Materias:
Cryptococcus neoformans
antimicrobial agents
antimicrobial peptides
drug synergy
fungal meningitis
fungi
Acceso en línea:https://journals.asm.org/doi/10.1128/spectrum.00439-22
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