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Glutathione maintenance mitigates age-related susceptibility to redox cycling agents
Isolated hepatocytes from young (4–6 mo) and old (24–26 mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to...
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| Main Authors: | , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2016-12-01
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| 叢編: | Redox Biology |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S2213231716301434 |
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