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Glutathione maintenance mitigates age-related susceptibility to redox cycling agents

Isolated hepatocytes from young (4–6 mo) and old (24–26 mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to...

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Bibliografiske detaljer
Main Authors: Nicholas O. Thomas, Kate P. Shay, Amanda R. Kelley, Judy A. Butler, Tory M. Hagen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-12-01
Serier:Redox Biology
Fag:
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231716301434
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