Identification of SOX2 Interacting Proteins in the Developing Mouse Lung With Potential Implications for Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia is a structural birth defect of the diaphragm, with lung hypoplasia and persistent pulmonary hypertension. Aside from vascular defects, the lungs show a disturbed balance of differentiated airway epithelial cells. The Sry related HMG box protein SOX2 is an important t...

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Main Authors: Kim A. A. Schilders, Gabriëla G. Edel, Evelien Eenjes, Bianca Oresta, Judith Birkhoff, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Jeroen A. A. Demmers, Raymond Poot, Rene M. H. Wijnen, Dick Tibboel, Robbert J. Rottier
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pediatrics
Subjects:
lung development
SOX2
congenital diaphragmatic hernia
CHD4
CUX1
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.881287/full
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