CD4 T cells mediate both positive and negative regulation of the immune response to HIV infection: complex role of T follicular helper cells and Regulatory T cells in pathogenesis

HIV-1 infection results in chronic activation of cells in lymphoid tissue, including T cells, B cells and myeloid lineage cells. The resulting characteristic hyperplasia is an amalgam of proliferating host immune cells in the adaptive response, increased concentrations of innate response mediators d...

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Main Authors: Chansavath ePhetsouphanh, Yin eXu, John eZaunders
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2015-01-01
Serija:Frontiers in Immunology
Teme:
HIV Infections
Lymphoid Tissue
regulatory T cells
CD4
T follicular helper cells
Online dostop:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00681/full
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