A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA)

Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder and the leading genetic cause of death in infants. Despite the disease-causing gene, survival motor neuron (SMN1), encodes a ubiquitous protein, SMN1 deficiency preferentially affects spinal motor neurons (MNs), leaving the basis...

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Hauptverfasser: Andrea Luchetti, Silvia Anna Ciafrè, Michela Murdocca, Arianna Malgieri, Andrea Masotti, Massimo Sanchez, Maria Giulia Farace, Giuseppe Novelli, Federica Sangiuolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2015-08-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
survival motor neuron (SMN)
spinal muscular atrophy (SMA)
neural stem cells (NSCs)
motor neurons (MNs)
microRNAs (miRNAs)
Online Zugang:http://www.mdpi.com/1422-0067/16/8/18312
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