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Ribosylation rapidly induces alpha-synuclein to form highly cytotoxic molten globules of advanced glycation end products.

BACKGROUND: Alpha synuclein (alpha-Syn) is the main component of Lewy bodies which are associated with several neurodegenerative diseases such as Parkinson's disease. While the glycation with D-glucose that results in alpha-Syn misfold and aggregation has been studied, the effects of glycation...

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Main Authors: Lan Chen, Yan Wei, Xueqing Wang, Rongqiao He
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science (PLoS) 2010-01-01
Sraith:PLoS ONE
Rochtain Ar Líne:http://europepmc.org/articles/PMC2816216?pdf=render
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