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Ribosylation Rapidly Induces α-Synuclein to Form Highly Cytotoxic Molten Globules of Advanced Glycation End Products

BACKGROUND: Alpha synuclein (α-Syn) is the main component of Lewy bodies which are associated with several neurodegenerative diseases such as Parkinson's disease. While the glycation with D-glucose that results in α-Syn misfold and aggregation has been studied, the effects of glycation with D-r...

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Detalhes bibliográficos
Main Authors: Chen, Lan, Wei, Yan, Wang, Xueqing, He, Rongqiao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816216/
https://ncbi.nlm.nih.gov/pubmed/20140223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009052
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